Uses
What is Voxzogo used for?
Voxzogo (vosoritide) is commonly used to increase growth in children born with a genetic condition affecting bone development (achondroplasia) who are still growing.
Voxzogo may also be used for other conditions as determined by your healthcare provider.
How does Voxzogo work (mechanism of action)?
In children born with achondroplasia, bone growth and development is slowed, causing their bones to be shorter than usual. Voxzogo affects signals in certain pathways in the body, which may help promote bone growth and development.
How is Voxzogo supplied (dosage forms)?
Voxzogo is available in the following dosage forms that are injected under the skin.
- 0.4 mg/vial
- 0.56 mg/vial
- 1.2 mg/vial
How should I store Voxzogo?
Voxzogo vials and diluent should be stored in the refrigerator, between 36 F to 46 F (2 C to 8 C). Do not freeze. Protect from light.
Before mixing, this medicine can be stored at room temperature, between 68 F to 77 F (20 C to 25 C), for up to 90 days. Do not use the medicine if it has been stored at room temperature for more than 90 days. Write the date you removed the medicine from the refrigerator to help keep track. Do not put the medicine back into the refrigerator after it has been stored at room temperature.
Side Effects
What are the most common side effects of Voxzogo?
The most common side effects of Voxzogo are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Redness, itching, swelling, hives, or pain at the injection site
- Rash
- Vomiting
- Joint pain
- Low blood pressure (see below)
- Stomach flu (gastroenteritis)
There may be other side effects of Voxzogo that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Voxzogo?
While less common, the most serious side effects of Voxzogo are described below, along with what to do if they happen.
Low Blood Pressure. Voxzogo may cause short-term episodes of low blood pressure. Tell your healthcare provider if you have any symptoms of low blood pressure, such as feeling weak or tired, dizziness, or nausea. Staying well hydrated and eating enough food prior to using Voxzogo helps reduce the risk of low blood pressure.
Severe Allergic Reactions. Voxzogo may cause allergic reactions, which can be serious. Stop using Voxzogo and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Warnings & Precautions
Who should not use Voxzogo?
Allergies to Ingredients. People who are allergic to any of the following should not use Voxzogo.
- Voxzogo
- Vosoritide
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Voxzogo.
What should I know about Voxzogo before using it?
Do not use Voxzogo unless it has been prescribed to you by a healthcare provider. Use it as prescribed. This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Voxzogo. If you have any questions, talk to your healthcare provider.
Eat a meal and drink 8 to 10 ounces of fluids within 1 hour before each injection. This helps reduce the risk of low blood pressure.
Do not use the same injection spot two days in a row. Do not inject into any painful areas or where your skin is red or swollen.
Do not share Voxzogo with other people, even if they have the same condition as you. It may harm them. Do not reuse or share needles with other people because you may get a serious infection.
Keep Voxzogo out of the reach of children. Since this medicine is generally kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.
What should I tell my healthcare provider before using Voxzogo?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Voxzogo is right for you.
Kidney problems. It is not known if or how kidney problems could affect Voxzogo. If there is a concern about the health of your kidneys, your healthcare provider may do tests to determine if they are working well enough to take this medicine.
Pregnancy. It is not known if or how Voxzogo could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.
Breastfeeding. It is not known if Voxzogo passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Voxzego while breastfeeding.
How can I get more information about Voxzogo?
For more information about Voxzogo, you can visit the manufacturer’s website at www.voxzogo.com or call them at 877-695-8826.
Interactions
Does Voxzogo interact with foods or drinks?
There are no known interactions between Voxzogo and foods or drinks.
It is unknown if drinking alcohol will affect Voxzogo.
Does Voxzogo interact with other medicines (drug interactions)?
There are no known interactions between Voxzogo and other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
Overdose/Missed Dose
What should I do if I accidentally use too much Voxzogo?
If you or someone else has used too much Voxzogo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Voxzogo?
If you miss a dose, take it as soon as you remember if it is within 12 hours of the scheduled time. If it is more than 12 hours after your scheduled time, skip the missed dose and only take the next dose at the usual scheduled time. Do not take double or extra doses.
Are you currently using Voxzogo (vosoritide)?
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