Stem Cell Transplant for Lupus - Topic Overview
Stem cell transplantation is the replacement of damaged bone marrow cells with healthy cells, or stem cells. It is generally done after powerful drugs have been used to wipe out the damaged immune system (immunoablation).
Stem cells are immature cells that are produced in the bone marrow. They can divide to produce more stem cells or mature into red blood cells, white blood cells, and platelets. In an experimental procedure, a small number of people with lupus (systemic lupus erythematosus, or SLE) have successfully been treated with their own stem cells.1
Doctors once advised women with lupus not to get pregnant due to the potential risks. But while pregnancy with lupus still carries its own set of risks, most women with lupus can safely become pregnant and have healthy babies. If you have lupus and are thinking about getting pregnant, here's what you need to know about the possible risks and complications. Here's also what you and your doctor can do to help ensure the best outcome for you and your baby.
Read the Pregnancy and Lupus article > >
Stem cell transplantation has serious risks. After a person's stem cells have been collected from the bloodstream, they are returned to the bloodstream along with a stem cell growth factor. If successful, the stem cells help the bone marrow return to a healthy state. However, during the two weeks that the immune system requires to become strong again, the body is extremely vulnerable to life-threatening infection.
Although several people have been disease-free at about 25 months after stem cell transplantation, this procedure is considered a high-risk, expensive, and experimental treatment for lupus.1
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